| Bioactivity | KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 μM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 μM[1]. |
| Formula | C51H65F4N9O9S2 |
| Molar Mass | 1088.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jianguo Chen,et al. Sulfonylvinyl compounds for the treatment of cancer. WO2024149819A1. 2024-01-11 |